Two sample MR report
HLA-A_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | -0.0500080 | 0.0565779 | 0.3907088 |
| Weighted median | 17 | 0.0608613 | 0.0088089 | 0.0000000 |
| Inverse variance weighted | 17 | 0.0541725 | 0.0063093 | 0.0000000 |
| Simple mode | 17 | 0.0662488 | 0.0144671 | 0.0003087 |
| Weighted mode | 17 | 0.0655285 | 0.0147935 | 0.0004207 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 8.686143 | 15 | 0.8933480 |
| Inverse variance weighted | 12.119456 | 16 | 0.7357165 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0508781 | 0.0274583 | 0.0836705 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002104 | 1e-07 | TRUE | 0.1744316 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
